Oren asks:

   "Assuming that you have no access to tooling, and you don't have the resources to built NHibernate-sque framework, how would you approach building a Domain Driven application on the naked CLR?"

The most interesting part of the question for me is "and you don't have the resources to built NHibernate" because it immediately goes to the seemingly basic assumption most people have these days that "Persistence => SQL".

While it might be certainly true that a relational backend is a given for most enterprisey scenarios it is certainly not true that all persistent applications have to go through the pain.

Once upon a time a team with 4 people (2 developers, 2 web designers) built the web content management system for the 3rd largest TV station in Brazil on top of System.Runtime.Serialization using the Object Prevalence architecture.

Yeah, skin naked CLR.

If your specific application can't afford keeping all its objects in memory all the time and you don't mind putting a little clothes on, there's db4o.